Glial proteins in canine distemper virus-induced demyelination
Identifieur interne : 001E22 ( Main/Exploration ); précédent : 001E21; suivant : 001E23Glial proteins in canine distemper virus-induced demyelination
Auteurs : M. Vandevelde [Suisse] ; P. Bichsel [Suisse] ; S. Cerruti-Sola [Suisse] ; A. Steck [Suisse] ; F. Kristensen [Suisse] ; R. J. Higgins [États-Unis]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1983-12-01.
English descriptors
- KwdEn :
- Teeft :
- Acta, Acta neuropathol, Adjacent section, Astrocyte, Astroglial, Astroglial changes, Astroglial infection, Berl, Canine, Canine distemper, Canine distemper virus, Canine distemper virus infection, Cell bodies, Cerebellar, Clear decrease, Demyelinating, Demyelinating diseases, Demyelinating encephalitis, Demyelinating lesions, Demyelination, Distemper, Distemper virus, Earliest lesions, Early distemper lesions, Experimental herpes simplex virus infection, Further progression, Glial, Glial fibrillary acidic protein, Glial proteins, Higgins, Itoyama, Kristensen, Lesion, Miles laboratories, Myelin, Myelin sheath, Myelin sheaths, Neuropathol, Oligodendroglial, Oligodendroglial cell body, Oligodendroglial infection, Plenum press, Present study, Primary lesions, Primary target, Progressive multifocal leukoencephalopathy, Raine, Same lesion, Segmental demyelination, Similar techniques, Spongy appearance, Subpial, Subpial cerebellar, Such lesions, Tural studies, Ultrastructural studies, Vandevelde, Webster hdef, White matter, York london.
Abstract
Summary: A temporal series of demyelinating lesions in experimental canine distemper virus (CDV) infection was examined with immunohistological techniques demonstrating myelin basic protein (MBP), myelin-associated glycoprotein (MAG), and glial fibrillary acidic protein (GFAP) on serial sections. The earliest lesions were characterized by decreased MBP and MAG and increased GFAP. During the further progression of the disease, MBP and MAG losses continued to match each other. There was no indication of MAG loss preceding the disappearance of MBP. In the more advanced lesions there was a marked decrease of GFAP positive cells. Since these findings differed considerably from similar immunohistochemical studies in progressive multifocal leukoencephalopathy (PML) where demyelination results from oligodendroglial infection, it was concluded that the oligodendroglial cell body is not the primary target of CDV. The marked astroglial changes were also considered to contribute to demyelination in CDV infection but the mechanism by which this happens remains unknown.
Url:
- https://api.istex.fr/ark:/67375/1BB-1LGWTVF7-C/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086711
DOI: 10.1007/BF00691492
Affiliations:
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Le document en format XML
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Vandevelde</name><affiliation wicri:level="3"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Comparative Neurology, University of Berne, Bremgartenstr. 109a, P.O. Box 2735, CH-3000, Berne</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Bichsel, P" sort="Bichsel, P" uniqKey="Bichsel P" first="P." last="Bichsel">P. Bichsel</name><affiliation wicri:level="3"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Comparative Neurology, University of Berne, Bremgartenstr. 109a, P.O. Box 2735, CH-3000, Berne</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Cerruti Sola, S" sort="Cerruti Sola, S" uniqKey="Cerruti Sola S" first="S." last="Cerruti-Sola">S. Cerruti-Sola</name><affiliation wicri:level="3"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Comparative Neurology, University of Berne, Bremgartenstr. 109a, P.O. Box 2735, CH-3000, Berne</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Steck, A" sort="Steck, A" uniqKey="Steck A" first="A." last="Steck">A. Steck</name><affiliation wicri:level="3"><country xml:lang="fr">Suisse</country><wicri:regionArea>Dept. of Neurology, University of Lausanne, CH-1000, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Kristensen, F" sort="Kristensen, F" uniqKey="Kristensen F" first="F." last="Kristensen">F. Kristensen</name><affiliation wicri:level="3"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Clinical Immunology, Inselspital, University of Berne, CH-3000, Berne</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation></author><author><name sortKey="Higgins, R J" sort="Higgins, R J" uniqKey="Higgins R" first="R. J." last="Higgins">R. J. 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The earliest lesions were characterized by decreased MBP and MAG and increased GFAP. During the further progression of the disease, MBP and MAG losses continued to match each other. There was no indication of MAG loss preceding the disappearance of MBP. In the more advanced lesions there was a marked decrease of GFAP positive cells. Since these findings differed considerably from similar immunohistochemical studies in progressive multifocal leukoencephalopathy (PML) where demyelination results from oligodendroglial infection, it was concluded that the oligodendroglial cell body is not the primary target of CDV. The marked astroglial changes were also considered to contribute to demyelination in CDV infection but the mechanism by which this happens remains unknown.</div></front></TEI><affiliations><list><country><li>Suisse</li><li>États-Unis</li></country><region><li>Californie</li><li>Canton de Berne</li><li>Canton de Vaud</li></region><settlement><li>Berne</li><li>Lausanne</li></settlement></list><tree><country name="Suisse"><region name="Canton de Berne"><name sortKey="Vandevelde, M" sort="Vandevelde, M" uniqKey="Vandevelde M" first="M." last="Vandevelde">M. Vandevelde</name></region><name sortKey="Bichsel, P" sort="Bichsel, P" uniqKey="Bichsel P" first="P." last="Bichsel">P. Bichsel</name><name sortKey="Cerruti Sola, S" sort="Cerruti Sola, S" uniqKey="Cerruti Sola S" first="S." last="Cerruti-Sola">S. Cerruti-Sola</name><name sortKey="Kristensen, F" sort="Kristensen, F" uniqKey="Kristensen F" first="F." last="Kristensen">F. Kristensen</name><name sortKey="Steck, A" sort="Steck, A" uniqKey="Steck A" first="A." last="Steck">A. Steck</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Higgins, R J" sort="Higgins, R J" uniqKey="Higgins R" first="R. J." last="Higgins">R. J. Higgins</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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